Abstract
Background: Species of the genus Adinandra are wild plants, and in-depth studies on their chemical constituents and biological activities have been conducted for only a few species, namely A. hainanensis, A. lienii, and A. poilanei, among the 17 Adinandra species recorded in Vietnam. Adinandra megaphylla Hu (Hong dam Sa Pa) is a rare and endangered species; however, to date, no studies have reported the isolation of compounds or the evaluation of their biological activities from this species. Objective: The objective of this study was to isolate compounds from the leaves of Adinandra megaphylla Hu and to determine their chemical structures and biological activities. Methods: Using thin-layer chromatography, column chromatography, and spectroscopic methods. Results: Three compounds were isolated and structurally identified from the leaves of A. megaphylla Hu: ursolic acid, 24-hydroxytormentic acid, and scopoline. Among these, 24-hydroxytormentic acid and scopoline were isolated for the first time from the genus Adinandra. Within the scope of this study, ursolic acid exhibited the strongest antibacterial activity against Pseudomonas aeruginosa and Streptococcus milleri. Scopoline showed cytotoxic activity against HepG2 and MCF-7 cancer cell lines, with IC50 values of 32.00 and 43.63 μg/mL, respectively. Ursolic acid and 24-hydroxytormentic acid demonstrated inhibitory activity against α-glucosidase, with IC50 values of 27.52 and 18.38 μg/mL, respectively.
| Published | 2025-12-31 | |
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| Issue | Vol. 4 No. 4 (2025) | |
| Section | Original article | |
| DOI | 10.66517/jstmp.2025.4.2 | |
| Keywords | Hồng đạm Sa Pa, Phân lập hợp chất, Hoạt tính sinh học, Chi Dương đồng, Kháng khuẩn Adinandra megaphylla Hu, Compound isolation, Biological activity, Adinandra genus, Antibacterial activity |
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