Abstract

Background: Atopic dermatitis is a specific response of dermatitis to both endogenous and exogenous factors. Exogenous factors include: climate, environment, chemicals, ultraviolet light, cosmetics, food... Endogenous factors such as genetics, chronic digestive disorders, parasites irritation, metabolic disorders, endocrine dysfunction. It is a place that is a psychological and social burden for the patient and his/her family. The biological indicators on the skin of people with atopic dermatitis are different from those of normal people Objective: To describe several skin biomarkers of patients with atopic dermatitis and determine the correlation between these biomarkers and clinic stages of the disease. Methods: Case-control and cross-sectional descriptive studies were carried out on 30 patients with atopic dermatitis. Results: Quantitative analysis of several skin biomarkers on the skin of patients with atopic dermatitis by a quantum resonance magnetic analyzer showed that there was a disorder in some indexes (increase or decrease) compared to normal people. An increase of skin skin biomarkers including immune index of 63.3% (3.91 ± 1.62), free radicals of 53.3% (3.91 ± 1.83), skin moisture loss of 60.0% (4.94 ± 1.55), subcutaneous fat of 80.0% (25.42 ± 4.81), skin's horny layer 83.3% (2.30 ± 0.55), melanin 96.7% (0.60 ± 0.15). A decrease was detected with collagen of 90.0% (3.20 ± 0.89), skin elasticity of 50.9% (2.30 ± 0.69). The difference was statistically significant (with p<0.05... and p<0.05). There was a positive correlation between the skin dilated capillary index and the clinical stages (corresponding to levels from mild to severe) in patients with atopic dermatitis (R = 0.44, p <0.05). Conclusions: There was an increase in skin biomarkers such as skin immunity, free radicals, skin moisture loss, subcutaneous fat, skin's horny layer, melanin and a decrease of collagen, skin elasticity. A positive correlation between the skin dilated capillary index and the clinical stages in patients with atopic dermatitis was showed.