Abstract

Background: Studies on patterns of neonatal morbidity and mortality indicate that up to 75% of neonatal deaths are related to preterm birth, and preterm infants have a higher risk of morbidity and mortality than term infants. The current rate of preterm birth in Vietnam is about 6.5% - 16%. The preterm infant‘s mortality rate accounts for 75.3% - 87.5% of neonatal deaths. Objective: Describe clinical and paraclinical characteristics and analyze some factors related to the results of treatment offor threatened preterm birth at Bac Ninh Obstetrics and Pediatrics Hospital. Methods: Rretrospective, descriptive, Ccross-sectional, retrospective, descriptive study on of 284 medical records of pregnant women with which have gestational age from 22 to 36 weeks and were treated with Nifedipine at the Obstetrics Department of Bac Ninh Obstetrics and Pediatric Hospital from 1st January 1 January 2021 to 31st December 31, 2022. Results: Subjects threatened with preterm birth: Age group 20 - 35 accounted for 83.5%, average age 27.68 ± 5.8; Mostly Kinh people (90.5%) and from rural areas (77.1%); The largest gestational age group with the highest risk of preterm birth is was 32 - 34 weeks (Accounting for 40.5%), 58.1% were nulliparousbabies and 20.4% had a history of abortion. Of the pregnant women admitted to the hospital, 67.6% had symptoms of abdominal pain, 39.4% had short cervical length, frequency of uterine contraction frequency  1 accounted for the majoritymainly (61.6%), frequency from 2 - 3 contractions per attacks/10 minutes accounted for 38%, and 84.5% had cervical dilation  1 cm; The successful pregnancy retention rate is 94.7%, the success rate offul pregnancy retention rate with Nifedipine is closely relatedhas a close relation with to the frequency of uterine contractions and the degree of cervical dilatation. Equation to estimate the ability to successfully maintain pregnancy with Nifedipine (94.4% accuracy): Log(Odds) = 7.337 - 1.533 x Cervical dilatation - 1.211 x Frequency of uterine contractions. Conclusion: The ability to maintain pregnancy with Nifedipine depends on many factors, good examinations and pregnancy management helps increase the rate of successful pregnancy retention.The gestational age group with the highest risk of preterm birth is 32 - 34 weeks, (40.5%), 67.6% had symptoms of abdominal pain, 39.4% had short cervical length, 61.6% had frequency of uterine contractions  1 and 84.5% had cervical dilation  1 cm. The success rate in treating threatened preterm birth at Bac Ninh Obstetrics and Pediatrics Hospital in the period of 2021 - 2022 was 94.7%. Cervical dilatation and uterine contraction frequency are two main factors affecting the success of treatment of threatened preterm birth with Nifedipine.